Sentence examples for crucial trigger from inspiring English sources

Under such conditions, the effect of an activating microenvironmental stress becomes a crucial trigger.

Since the seminal experiments of Ringer on cardiac muscle contraction [32], it has been recognized that Ca2+ entry into cells provides a crucial trigger for life and death processes.

Since inflammation of visceral fat is a crucial trigger of atherogenesis, decreased visceral fat in PGC-1α-deficient mice may explain why these mice do not develop enhanced atherosclerosis.

Structurally it is closely related to α-synuclein and shares its ability to aggregate in vitro 16, 17 and in vivo, 18 which is believed to be a crucial trigger of neurodegeneration in α-synucleinopathies.

Overall, the division employed and led a clear and simple approach to the implementation of the program in each practice and this was seen as a crucial trigger for change.

Even though there is an equal possibility for genes that are deleterious to be switched on through changes in the enzymes that alter the epigenome, it would seem that the switching off of genes is the crucial trigger for the progression of tumours through altering the inherent stable balance in cells.

High motivation to change is a crucial triggering factor to patients' engagement in clinical treatment.

Although the mechanisms of cell loss are being uncovered the crucial triggers that modulate epithelial turnover through regulation of cell loss remain undetermined.

These results indicate that Ca2+ ions in the postsynaptic neurons are crucial triggers for CP-AMPAR-dependent LTP, similar to their role in traditional NMDAR-dependent forms of plasticity (Figure 4C; control = 236±20.8%; BAPTA = 95±9.5%; P<0.001).

All these observations lead to a really complex but fascinating picture, where mitochondrial Ca2+ signals represent crucial triggers of apoptosis.

Hypoxia and HIF, major contributors to the pathogenesis of PH, have been thought to act as crucial triggers for miRNA dysregulation in PH.