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The strain proved a crucial setback in his lifelong battle with alcohol, and he relied increasingly on the bottle to help him deal with the strains of office.
Ms Stewart, a friend of the company's founder Sam Waksal, sold the shares a day before the firm announced that it had suffered a crucial setback in the development of a potentially blockbusting cancer drug.
Likewise, when Reed is banished en route for killing a teamster in a scuffle, and Margret and the children are left at the mercy of the rest of the group, Rarick sees a crucial setback for the Donner party, the loss of its "one true leader".
The loss of four large attack carriers, including Kaga at Midway was a crucial setback for Japan, and contributed significantly to that nation's ultimate defeat.
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In the co-channel approach shown in Figure 1a, while the spectrum resources are fully reused in different tiers, cross-tier interference may cause crucial setbacks to the system.
A crucial 1964 setback for feminism, that.
"Having suffered several setbacks at crucial points, I believe I'm no longer on a pathway which will see me fulfil my Olympic ambition to win a second Olympic gold medal," said Romero.
Tory leaders also talk up their prospects, such that anything less than an outright victory for Mr Farage's party which he has rashly promised will be spun as a setback.The crucial context for this uncharacteristic Tory discipline is a steady uptick in the party's ratings as the economic recovery proceeds.
And his ability to conjure that tradition for support is another reason individual setbacks were less crucial for him.
Because of these long-lasting setbacks, it's crucial that we address this problem before LGBT youth are cast off onto the streets.
Epiphany After a Setback She made a crucial first step toward that goal one summer night when she was too wired to sleep.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com