Its development, the necessary crucial refinements, however, depended on the use of a human guinea pig.
Joachim Frank, a biochemist at Columbia University, and Jacques Dubochet, of the University of Lausanne, in Switzerland, made crucial refinements to the method and widened its application.
The crucial refinements he made — including a corner mechanism that locks containers together — allowed them to be hefted by crane, stacked high in ships and transferred from shipboard to trucks and trains far more easily, and cheaply, than ever before.
Activity-dependent mechanisms are crucial for the refinement of neuronal circuits (Van Ooyen et al. 1995; Butz et al. 2009), but activity seems to have a lower influence on the early connectivity in neural systems.
This refinement is crucial in the present context.
Prior to the study, which was focused on the influence of the control of temperature over the catalytic results, PID process parameters of the catalytic reaction system were optimized showing that the unit control refinement is crucial for a good performance of the catalytic tests.
miRNAs are the most abundant class of small non-coding RNAs, and they are involved in post-transcriptional regulations, playing a crucial role in the refinement of genetic programming during plant development.
The above refinements are crucial to our benchmark assessment being readily adopted by teachers and school authorities for utilization for its intended purposes, in pre-service and in-service training sessions or in post-observation discussions, as a basis for the professional development of Japanese EFL teachers.
Both are clearly unrealistic, so our ability to gauge their effect on model predictions is crucial to future model refinements.
That crucial development finds its ultimate refinement in the most recent tabletop trend, the "co-operative game", whereby every player wins or loses as a team member, whether fighting fires (Flash Point) or saving the world from infection (Pandemic).
