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A crucial problem with Mr. Caliban's two-hour show is that the band doesn't markedly improve in musicianship from its flustered initial concert to later, when the members supposedly are megastars.
The crucial problem with this procedure is how to avoid mere circular reasoning, or rather, how to make sure that the cause, whose existence is demonstrated in the first step, is indeed the cause of this very effect.
For example, a crucial problem with the applications of these option-pricing formulas in the fractional Black Scholes market in practice is how to obtain the unknown parameters in geometric fractional Brownian motion (hereafter gfBm).
The spatial arrangement of urban hubs and centers and how individuals interact with these centers is a crucial problem with many applications ranging from urban planning to epidemiology.
Furthermore, our data revealed a crucial problem with the assessment of any prognostic factor.
Bortezomib is one of the most effective chemotherapies for MM, but drug resistance remains a crucial problem with bortezomib treatment.
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But one of the crucial problems with the £8bn care home "market" is that few consumers are in a position to take rational, informed, decisions.
It's hard to disentangle this macramé of material, but Hobson, a professor of psychiatry at Harvard Medical School, and Leonard, a medical writer, do get at most of the really crucial problems with psychiatry today.
However, Alice and Bob meet a crucial problems with designing their security procedure (e.g., hash function) which would guarantee that Eve is left with no information about the final key.
One of the crucial problems with ChIP-based genome-wide assays, including ChIP-seq, is a statistically reliable identification of biologically meaningful phenomena (e.g. all specific and functionally important binding loci) from the large amounts of generated experimental data.
One of the crucial problems with cDNA display is the low yield of cDNA-protein fusion molecules, which is less than 1% of input mRNA-linker conjugates [ 8, 12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com