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Addition of hydroxychloroquine improved endosomal escape and increased siRNA guide strand distribution to the RNA induced silencing complex (RISC), both crucial obstacles to the potency of siRNA.
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A crucial obstacle to implementing the recommendations could be cost.
To succeed in this, though, the ship would have to overcome a crucial obstacle: speed.
It is increasingly clear that the settlements are a crucial obstacle to a resumption of meaningful peace talks.
But it turns out that no sooner have you identified one supposedly crucial obstacle than another appears behind it.
A particle that barely ranks as a footnote in a physics text may be about to lift the cleanup of the stricken Fukushima Daiichi nuclear complex in Japan over a crucial obstacle.
Nicholas Kristof's description of the many barriers Dr. Tererai Trent successfully overcame fails to mention one crucial obstacle faced by today's dreamers ("Triumph of a dreamer," Views, Nov. 16).
But if Kennedy was seeking to use the fake identity provided by police to continue his life as a spy, there was one crucial obstacle: he would almost certainly have had to hand in his fake driving licence and passport, meaning he would need to travel abroad under his real name.
A new, mostly Protestant landed class posed a crucial obstacle to his daughter, Mary, in her attempt at counter-Reformation and then aided his second daughter, Elizabeth, in reversing the counter-Reformation and ensured the Stuarts, when they sought to assert "the divine right of kings", encountered overwhelming opposition from a new breed of parliamentarians.
The agreement, which has yet to be ratified in the Turkish or Armenian Parliaments, could have broad consequences, helping to end landlocked Armenia's economic isolation, while lifting Turkey's chances for admission into the European Union, where the genocide issue remains a crucial obstacle.
Line speed is the crucial obstacle currently holding back the wireless market.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com