In the B cell compartment it also appears as if Pax-5 is crucial to lock the cell in the B-lymphoid developmental pathway.
Chait seems to think that the "extensive terminology" born out of the identity politics moment is itself the problem; he claims that so-called p.c. language "plays a crucial role, locking in shared ideological assumptions that make meaningful disagreement impossible".
In such an "agnostic" (in Huxley's meaning) situation, one of the very few intellectual pursuits that a theoretician could afford to accept as not being hopelessly speculative would be to examine, by all conceivable means (including in vitro experiments with aa-specific RNA aptamers), the crucial "key-lock vs. frozen accident" alternative.
Randolph wrote, "The message to the Met's management is crucial: don't lock out the talent, represented by the unions.
Thus, in Part II of this interview, we tackle such colorful subjects as Herzog's anti-romantic views on nature, why he can't help ranting about Avatar, his excitement over his Rogue Film School (in which he teaches such crucial skills as "lock picking" and "neutralizing bureaucracy"), and his belief that Wrestlemania and reality TV offer vital clues to understanding civilization.
It should do so only a month after filing for bankruptcy protection, thanks to some crucial agreements it locked down beforehand with its union workers and some debt holders.
Party officials say the effort, at a cost of $6 million, locked down crucial votes for the Democratic candidate, Janet Napolitano, weeks before the election.
And then came the crucial mistake, when he locked the rear tyres going into Turn Four and ran wide into the run-off area, half-spinning.
Appreciating uncertainty is crucial to avoid being locked into an incomplete and, possibly, incorrect, mental model (a cognitive error sometimes called 'premature closure').
The Wasps lock made some crucial tackles.
