A third mechanism by which docking proteins can be negatively regulated by protein phosphorylation is via changes in their "social behaviour", specifically alterations in their ability to interact with crucial interaction partners or in their subcellular localisation (Fig. 6D; [ 4]).
The Schneiders were desperate for some activity for their boys to focus on — one that would bring crucial interaction with nonautistic children and allow a physical outlet for their boundless energy.
Our studies suggest a new and crucial interaction (KasB-Pks13) as a putative target for peptidomimetic antibiotics.
Since the crucial interaction between pro- and anti-apoptotic members occurs via a conserved region located on the surface of the protein, a viable way to inhibit the anti-death activity of Bcl-2 proteins is to design small molecule inhibitors that occupy this cavity.
Adhesins are known to facilitate host colonization by mediating the first and crucial interaction with host tissue [10].
This may be an indirect consequence of the base flipping defect in this mutant which would reduce the crucial interaction between the flipped base and the stacking tryptophan.
