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The modulatory feedback connections, that exist between different model components and allow the transfer of information via a "soft gating" mechanism, are crucial for the functionality of the model.
Note that the chosen order of the blocks is not crucial for the functionality of the SuperGenome concept.
The biophysical properties of biological membranes are crucial for the functionality of membranous organelles, including the mitochondria and ER.
In addition to being crucial for the functionality of many individual proteins, intrinsic disorder plays a vital role in the control of almost all cellular processes.
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Improved techniques for integration of data arising from different sources, as well as for visualization, will be crucial for understanding the functionality of complex networks.
Instability is crucial for impairing the functionality of missense mutant pVHLs.
Crucial for the correct functionality and sensitisation of these signalling cascades are negative feedback mechanisms such as the repressors of G-protein signalling (RGS) and the cAMP phosphodiesterases.
We uncover the exceptional adsorption behavior of individual [AuIII TPP)]+ adsorbed on Au(111), and provide a bonding scheme explaining the origin of the AuIII-oxidation-state stabilization crucial for the medical functionality.
These secondary structures are likely to be under strong selective pressure and might be crucial for the ncRNA functionality, similarly to other highly structured RNAs (Shabalina and Koonin 2008).
The N-terminal tyrosines Tyr53 (in Spry1 and Spry4) and Tyr55 (in Spry2) are also conserved residues crucial for the Sprouty functionality to the extent that their corresponding dominant-negative mutants fail to attenuate ERK signaling and even repress the function of the wild type (WT) protein [ 60, 72, 76, 89, 99].
Motor neurons produce SS-B/z+ Agrin, which is crucial for the stabilization and functionality of the NMJ.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com