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It is well-established that homophilic binding of Dscam1 isoforms is crucial for proper functioning in a physiological setting.
Furthermore, we have been able to show that the conserved residues D242 and H338 are crucial for proper functioning of this type of peroxidases.
Iron homeostasis is crucial for proper functioning of the organism, and while iron deficiency leads to anemia, its excess may cause severe symptoms.
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In line with these findings, our results suggest that three-dimensional islet architecture is not crucial for proper function of the cellular oscillator.
This highly elaborated arrangement is thought to be crucial for proper function of neuronal networks (Douglas and Martin 2007; Markov et al. 2013).
These results suggest that the inside-out activation of the α5 β1-integrin mediated by ERdj3/Prtg/Radil signaling is crucial for proper functions of R-CNCCs, and the deficiency of this pathway causes premature apoptosis of a subset of R-CNCCs and malformation of craniofacial structures.
Anyhow, tuning of these algorithms, especially Kalman filter, is a crucial task for proper function, but systematic guidelines or algorithms are not existing.
Overall, an appropriate balance between adipogenesis and lipolysis is therefore crucial for the proper functioning of adipose tissue, which plays an important role in obesity and associated metabolic functions.
Stabilization of proteins is crucial for their proper functioning.
The good bonding of the composite elements is crucial for the proper functioning of timber composite structures, as the design capacity and performance of the system cannot be achieved unless an adequate connection condition can be assured.
The cell wall binding domains are crucial for the proper functioning of both murein and pseudomurein hydrolases.
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