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Recent studies have demonstrated that MET was crucial for circulating tumour cells in the blood to seed and establish early metastatic lesions at distant sites (Baum et al, 2008; Leontovich et al, 2012).
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The β2 integrin is crucial for the adhesion of circulating leukocytes to endothelial cells via binding to ICAM-1.
This may be interpreted as local IL-6 in the joint being crucial for the nociceptive response, while circulating IL-6 is not.
The two men, inherently distrustful of one another, possess a genuine chemistry, however one that becomes crucial when rumors circulate that Mangwana is advocating for a constitutional structure that could make him the next man to disappear or suffer a mysterious car accident.
In addition, the Fc region is crucial for the prolonged serum persistence of circulating IgG antibodies through an intracellular trafficking and recycling mechanism.
In renal allografts, it has been demonstrated that there was defective T-cell priming in the absence of local synthesis of C3 [ 26], suggesting that locally produced C3 is more crucial for acute cellular rejection than the circulating host derived C3.
The systemic circulating immune cells may be crucial for the phenotype.
The well-known vascular endothelial growth factor (VEGF) signaling is crucial for sprouting angiogenesis as well as recruitment of circulating progenitor endothelial cells to tumor vasculature, which has become therapeutic targets in clinical practice.
Sawyer described the network as "crucial" in terms of circulating information in effected areas.
This gives a crucial improvement in generating circulating state shifts more feasibly.
The results of the FTY720 treatment studies suggested that the availability of circulating T cells was perhaps not crucial for arthritis development.
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