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Background: Transforming growth factor-β1 (TGF-β1) is a profibrotic cytokine suspected to be a crucial factor underlying glomerulosclerosis in advanced diabetic nephropathy.
Notably, epidermal growth factor receptor (EGFR) is also up-regulated by IFN [21], and this up-regulation of EGFR is a crucial factor underlying the susceptibility of affected cancer cells to anti-EGFR antibody therapy [22].
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Together with the observation that reduced α-Klotho is associated with coronary artery disease [ 10], these findings suggested that modulation of FGF23/α-Klotho may represent one of the crucial factors underlying the cardiac [ 11] and vascular remodeling observed in patients with CKD.
Moreover, XML may become the most crucial component underlying the next big leap on the Internet.
Existing large population-based surveillance systems, if integrated with appropriate genetic material, could contribute crucial hypotheses and generate data to identify host factors underlying infectious diseases.
The authors' findings show that ND2 has a crucial role in the proton pumping mechanism of complex I, and point towards deficits in energy production as etiological factors underlying the pathogenesis of complex I deficiency.
Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps.
Experts say the factors underlying campus hunger are complex.
The factors underlying the malignant transformation of MGUS are unknown.
Genetic factors underlying these phenotypes overlapped.
We consider factors underlying these two approaches.
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