Sentence examples for crucial defect from inspiring English sources

These findings led us to the hypothesis that an unanticipated crucial defect resulting from the elimination of IL2 might be a lack of a negative regulatory feedback function [7].

With the continuous presence of insulin resistance, progressive loss of β-cell function is the crucial defect.

The earlier the gonadal development program is interrupted by a crucial defect, the less the gonad is able to differentiate into either a testis or ovary.

Actually, decreased activities of NADH-cytochrome c reductase are observed even in 4-week-old SAMP8 mice, suggesting crucial defects in maintenance of the respiratory chain [ 63].

This system may be suitable for the study of other neurodevelopmental and neuropsychiatric syndromes in which there are moderate but crucial defects in cortical organization and function.

However, this method cannot simulate the chemical reaction dynamics at reaction temperatures, which is crucial fault and defect for more precise and accurate design to establish next-generation nanotechnology.

Voids are crucial point defects that are inevitable during fabrication and deformation of materials.

Cracks are the main source of failure in the production of metal parts: systems for checking their presence are therefore crucial for defect-free production.

It is further concluded that the incident ion energy does not affect the formation of defects but rather ion fluence plays a crucial role in defect creation.

Therefore, because Chd1l responds to DNA damage through its interaction with PAR, and because DNA repair is crucial during embryogenesis, defects in DNA repair could underlie the Chd1l early embryonic arrest.

Objective: The initial attachment of transplanted chondrocytes to the surface of a cartilage defect is crucial for the success of chondrocyte transplantation.