Sentence examples for crucial active from inspiring English sources

The results show that the presence of a sugar acceptor binding-site, the fine-tuning of protein substrate interactions and the flexibility of crucial active site residues are all important to achieve transglycosidase activity from the TrSA sialidase scaffold.

The 20S core particle of the proteasome harbors β5 subunit which is a crucial active site in proteolysis.

Furthermore, a homology modeling and site-directed mutagenesis studies predicted the active site architecture, which suggested the crucial active site residues for the observed substrate preference.

Inhibitor binding is accompanied by a structuring of the region comprising residues Tyr71 Gly80 from being mostly disordered in the apoenzyme and leading to positioning of crucial active site residues for establishing enzyme inhibitor contacts.

Loop 1 contains crucial active site residues, including Ala134 His136, which form a snug pocket for lesion bases.

Positional rearrangements in Cdk2 result in proper alignment of crucial active site residues that are involved in ATP orientation and magnesium coordination.

As a result of this conformational change, the phenolic ring of Tyr80 can stack with the adenine group and catalysis proceeds (Figure 2a), whereas the side-chain conformation of another catalytically crucial active-site residue of RTA, Tyr123, remains unchanged upon the rRNA binding.

In both the R517A and R517K mutant simulations, changes occur to other crucial active-site residues in addition to the mutant residue.

This gives a new role for education system whose new task should be boosting creativity which is required not only in a workplace but is crucial for active citizen and consumer (Shapiro et al. 2007).

Vision-based pedestrian detection for intelligent vehicles applications is a crucial and active research area due to the essential benefits in terms of reducing the number of accidents involving pedestrians and vehicles.

Mycobacterium tuberculosis DNA gyrase, an indispensable nanomachine involved in the regulation of DNA topology, is the only type II topoisomerase present in this organism and is hence the sole target for quinolone action, a crucial drug active against multidrug-resistant tuberculosis.