Sentence examples for crucial activating from inspiring English sources

The present study extends our previous finding [ 1] that PAR-2 plays a key role in mediating chronic joint inflammation, by demonstrating that tryptase may be a crucial activating protease required for such PAR-2-mediated actions.

This dependence on shear stress is believed to limit leukocyte interactions in the center of vessels or in vessels with very high or very low wall shear stress, and the steady rolling generated enables the leukocyte to receive crucial activating stimuli from the endothelium.

However, in SPAK243A/243A mice, we observed ∼2.6-fold (Thr53), 7.2-fold (Thr58-crucial activating residue) and 4.6-fold (Ser89) reduction of NCC phosphorylation (Fig 3A).

These data indicate that derailed PP2A activity is crucial for activating apoptin in accordance with the data obtained in our SV40 transformation assay.

The rearrangements result in ligand-independent activation of RET tyrosine kinase which is considered crucial for activating the cellular signaling pathways involved in transformation of thyroid cells.

Replacement of Y596 with a glutamic acid residue completely restored EphA3 kinase activity (Fig. 2B), suggesting that the negative charge on Y596 is crucial in activating EphA3.

A conserved Asp adjacent to the catalytic acid (Asp302 in LeHex20A) is crucial for activating the acetamido group (Williams et al. 2002).

Future valuation is crucial to activating the part of the brain in a child that says, "If you do this now, there's a chance that your life will be better a year from now," -- generic consciousness raising about ownership and time.

Antigen processing and presentation is crucial for activating T cells and mounting protective immune responses.

Importantly, CpG3 has been demonstrated to be crucial for activating the CD44 promoter when demethylated (Kagara et al., 2012).

In particular, the enhancement of NO synthesis in close proximity to nuclei is crucial for activating the cAMP response element-binding protein (CREB) via S-nitrosylation.