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Hence, it cannot be concluded that the CRT combination evaluated here provided a greater activity than either agent alone due to limited dose escalation.
Although regional failure is potentially a significant problem in anal cancer, 30 Gy appeared to be adequate for even macroscopic disease in the series of 45 patients from Nigro's group, suggesting high intrinsic sensitivity of this disease to the CRT combination (Nigro et al, 1983).
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Implantable cardioverter defibrillators (ICD), cardiac resynchronisation therapy pacemakers (CRT-P) and the combination therapy (CRT-D) reduce all-cause mortality compared with medical therapy alone.
Implantable cardioverter defibrillators (ICD), cardiac resynchronisation therapy pacemakers (CRT-P) and the combination therapy (CRT-D) have been shown to reduce all-cause mortality compared with medical therapy alone in patients with heart failure and reduced EF.
We are not aware that any other combination CRT study has reported such data.
With four-color CRT applications, this combination provides good flexibility for the utility of the ring system, as a linker can be attached to the 4-position to create dye-labeled analogues.
Seven sequential CRT patients received carboplatin‐based combination chemotherapy, and one patient received cisplatin‐based combination chemotherapy.
CRISPR regions were predicted using a combination of CRT [ 145] and PILER [ 146].
Furthermore, a therapy in which SOX4 is targeted in combination with CRT might overcome apoptotic resistance and improve response in HNSCC.
In summary, there is a possibility that induction chemotherapy may improve survival in locally advanced HNSCC in combination with CRT as suggested by lower level evidence.
Results of this phase II study showed that S-1 in combination with CRT resulted in encouraging activity, with a clinical complete remission rate of 64.4% in patients with unresectable locally advanced SCCHN.
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