Declercq, W., Berghe, T. V. & Vandenabeele, P. RIP kinases at the crossroads of cell death and survival.
Regardless, our data provide evidence that inhibiting class I HDACs regulates the transcriptional activation of pro-survival pathways in response to ototoxic insult by regulating the acetylation status of transcription factors found at the crossroads of cell death and survival in the mammalian inner ear.
Ofengeim, D. & Yuan, J. Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
Serving a critical role in selective degradation of ubiquitinated substrates via autophagy, p62 (also called SQSTM1) is a receptor for Ub and LC3, potentially acting as a sensor of protein stress at the crossroads of cell survival and cell death.
RIPK1 is a kinase at the crossroad of life and death, and has a central role in the signaling pathways activated downstream of several TNFR and Toll-like receptor (TLR) family members.
Second, both caspase-independent cell death and apoptosis, particularly when related to the engagement of death receptors (DRs) or Toll-like receptors (TLR) by their respective ligands, critically involves the kinase RIP (Receptor interacting protein), which is currently seen as one of the crucial, and redox sensitive, cellular crossroads determining whether cells live or die.
As Nelder writes in his latest column, we find ourselves at a potentially exciting crossroads: the literal death throes of the fossil fuel industry, amidst the inexorable, sporadic rise of a new renewable energy system.
The crossroads of the world.
