He seemed to arrive at the crossroads where age tips the benefits of experience.
Here we provide our perspective on recent findings suggesting that de novo biosynthesis of purine nucleotides, which is based on the metabolism of one-carbon compounds, is a new target for metformin's actions at the crossroads of aging and cancer.
Being at the crossroad between ageing and metabolic imbalance, these findings point to miR-34a induction as an important risk factor for the development of type 2 diabetes.
China is currently at a crossroads with an aging population and steadily decreasing economic growth rates.
The Terminate the Rate campaign includes Age UK, Crossroads Care and Carers UK who work with the vulnerable all day, every day and know their experience.
Spears also dabbled in acting, making her big-screen debut in 2002 with the lead role in the coming-of-age film Crossroads.
In summary, we suggest that Sestrins are uniquely poised at the crossroads between stress and aging to adjust the metabolic timbre of an organism to meet its needs under normal conditions and to respond to predictable forms of environmental stress.
These are works of law and history, science and medicine, poetry and theology, relics of Timbuktu's golden age as a crossroads in Mali for trade in gold, salt and slaves along the southern edge of the Sahara.
Middle age is a crossroads, folks.
It's different when an ageing athlete hits the crossroads and, as time closes in, the old intensity withers away.
