Exact(2)
OS is also affected by treatment crossover upon disease progression [3] In solid tumours, phase II end-points are generally based on the Response Evaluation Criteria in Solid Tumours (RECIST) [4].
Seventy-one adults with advanced STS who received ⩽2 prior chemotherapeutics were randomized to selumetinib 75 mg p.o. bid and allowed to crossover upon progression, or to selumetinib 50 mg p.o. bid plus temsirolimus 20 mg i.v. weekly, with primary endpoint of progression-free survival (PFS).
Similar(58)
The third trial was a randomised multicentre phase II trial of oxaliplatin plus irinotecan vs raltitrexed as first-line treatment with a crossover design upon progression (Scheithauer et al, 2001c): patients randomised to the combination arm, were treated with oxaliplatin 85 mg m−2 and irinotecan 175 mg m−2 every 2 weeks.
Note: The perchlorate analogue was also prepared and showed thermal spin-crossover behavior upon cooling in liquid nitrogen.
Production of the compact crossover commenced this week, upon completion of a $680m expansion to this gleaming factory, which already produces the Cayenne SUV.
What are the internal temporal characteristics of such dynamics and how do the temporal features of network activity alternate upon crossover from minimal networks to large networks?
Understanding how the electrical activity properties vary upon crossover from single neurons to the network level, may provide the insight needed to reveal the innate properties of neuronal network dynamics.
The study was placebo-controlled in order to definitively establish the activity of pazopanib, and provided placebo subjects the opportunity to crossover to pazopanib upon progression.
Using the cycling conditions from Milano & Tang [ 31], the crossover rate decreases upon increasing annealing/extension time, yielding a lower survival rate on ampicillin.
The second crossover can occur upon displaced pairing between the anterior gene on one parental chromosome and the posterior gene on the other, yielding an anterior/posterior fusion gene, specifying the middle of the animal and resembling the Urhox gene more closely (fig. 9 D ).
Furthermore, we investigate the impact of capacity noise on parameter settings and we perform a comparison to genetic algorithms based upon PMX crossover.
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