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The ERP results in experiment 1 revealed crossover patterns in the left hemisphere (LH) and the right hemisphere (RH).
The reviewer raises valid points concerning regional variation in crossover patterns along chromosomes, and also variation between male and female meiosis.
The prevalent co-conversion of polymorphisms at CO sites prohibits the formation of complex crossover patterns of alternating polymorphisms, which implies that it is the COs themselves that diffuse haplotype borders, rather than their associated gene conversions.
We show in the Supplementary Material that the distribution of recombinants can be calculated in steps for arbitrary crossover patterns and in steps if only a single crossover is allowed.
CEN3 is largely heterochromatic, which is known to be inert for recombination and we have previously shown that DNA methylation in this region is important for normal crossover patterns (Yelina et al., 2012, PLoS Genetics).
Lack of significant correlations in the haploid family may be due to reduced statistical power from the limited number of observations; the similar patterns observed between the haploid and diploid families lead us to conclude that interference does affect crossover patterns across centromeres.
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The trial followed a complicated double-blind crossover pattern, with the doses, and hence Sam's behavior, changing week to week.
Six of 14 HCs showed a similar crossover pattern to the Mig group, although the difference in slopes was smaller.
The crossover pattern (as assessed by the interaction between race and the smooth line) is statistically significant (p < 0.0001) for both birth weight and gestational age. Figure 2 shows the association between neonatal mortality and relative birth weight.
At suprathreshold contrasts we found a marked difference between migraineurs and controls in the slope of the increment threshold functions resulting in a crossover pattern for migraineurs but not controls.
The earlier onset is emphasized by a prominent crossover pattern to the incidence of breast cancer between these two ethnic groups, resulting in a lower incidence among older African American women [ 30, 33].
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