Sentence examples for crossover outcome from inspiring English sources

In most organisms, the formation of the synaptonemal complex (SC) is instrumental in reinforcing pairing and ensuring a proper crossover outcome of the molecular recombination process (see Page and Hawley 2004; Kleckner 2006).

Mus81-Mms4/Eme1, Slx1-Slx4, and Yen1/Gen1 structure-specific endonucleases also process in vitro single or double HJs, and during double-strand break (DSB) repair their action leads to crossover outcome (exchange of DNA sequences between the donor and the recipient) (Ip et al, 2008; Ho et al, 2010; Wechsler et al, 2011; Munoz-Galvan et al, 2012).

If one mechanism by which the S-phase checkpoint suppresses mitotic crossover is via temporal restriction of the Mus81 pathway outside S phase, then the increased crossover outcome associated with replication checkpoint mutations should be to some extent dependent on Mus81-Mms4.

We found that MMS4 deletion partially decreases the crossover outcomes in all S-phase checkpoint mutants analysed: rad53, mrc1-AQ, and srs2.

Consistent with previous results, these different checkpoint mutations affect crossover outcomes to varying degrees: mrc1-AQ has a modest effect, rad53 has a stronger increase in crossover, but smaller than srs2 (Robert et al, 2006).

Rather, there is a change in the distribution of undifferentiated recombination intermediates into crossover versus non-crossover outcomes.

Joint DNA molecules are key intermediates in recombination and their differential processing determines whether the genetic outcome is a crossover or non-crossover event.

The relationship between diagnostic crossover and ED outcome remains unclear.

We identified here that Mus81-Mms4-dependent resolution is crossover prone in outcome, and its precocious activation leads to faulty replication of damaged templates, as well as to formation of deleterious crossovers associated with chromosome translocations in unperturbed conditions.

We have recently shown that regulation of the length of extension by Srs2 correlates with the increase in crossover frequency, an outcome that could be deleterious for mitotically dividing cells [31].

To determine the overall long-term effectiveness of treatment with epidural corticosteroid injections for lumbar central spinal stenosis and the effect of repeat injections, including crossover injections, on outcomes through 12 months.