In contrast, expelling the T-segment from the enzyme would be facilitated by the repulsive interaction between the DNA segments within a left-handed crossover generated by the reaction ("push").
Intrachromatid gene conversion associated with a crossover generates a chromosomal deletion and an episomal circular product.
Under the HSC model with two hotspots, crossover generates a symmetrical pattern of LD blocks in both duplicates.
There is no tandem repeat of Vtg genes found in the genomes of genus Culex, Aedes or Ochlerotatus, suggesting that gene conversion rather than unequal crossover generated the concerted evolution of Vtg genes in these mosquito species.
Besides the observed gene conversion events, recurrent unequal crossovers generating the same RCCX structure occurred several times.
Tandem duplications are clearly an important engine generating new gene copies in genomic clusters, where unequal crossovers generate new diversity.
The number of crossovers generated during the meiosis of F1 hybrids followed a Poisson distribution with a mean of 35.6 per meiosis (Kao et al. 2010) and the crossovers were randomly assigned to the genome.
The monophyletic groups were often created by single unequal crossover, whereas recurrent unequal crossover events generated some of the polyphyletic groups.
Microsatellites have also been associated with increased genomic diversity by promoting sequence duplications, gene conversion, crossovers, and generating local recombination hotspots [ 45, 48- 52, 53] 53].
First, it triggers resolution of double holliday junctions created through the repair of Spo11-induced double strand breaks, to produce reciprocal crossovers, thereby generating bivalent chromosomes [ 44].
