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It is found that for each ITCHY library, checking crossover distribution is also important.
The crossover distribution in nbs1-2 is altered relative to that in wild-type.
The homology gap apparently alters crossover distribution but not the interference (Hammarlund et al. 2005 ).
The mechanisms used to control crossover distribution are poorly understood (reviewed in Phadnis et al. 2011; Youds and Boulton 2011).
To distinguish between these two mechanisms, we sought to examine genome-wide crossover distribution in the msh4 –R676W hypomorph.
Thus, these restrictions may be largely a result of evolutionary adjustments of crossover distribution along the chromosome.
Similar(37)
Understanding the mechanisms underlying crossover control has been hampered by the difficulty in determining crossover distributions.
Such effects (crossover re-distribution along the chromosome and relaxation of interference) were also displayed by mei-mutants with increased recombination rates [ 70].
To demonstrate the advantage of the two-step method, we compared it with various evolutionary searches, such as Unimordal Normal Distribution Crossover (UNDX), UNDXm, Blend Crossover (BLX), and Simplex Crossover (SPX) [15] [17], by using a theoretical model (Text S1 and Equations S1-S5 in Text S1).
The Unimordal Normal Distribution Crossover (UNDX) is employed as crossover [17], while mutation is not used.
In the presented method, Unimodal Normal Distribution Crossover (UNDX) and Minimal Generation Gap (MGG) model are used as crossover operator and generation-alternation model, respectively.
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