Most importantly for studies of ALS, these mice have an increased susceptibility to neurodegeneration, for example, when crossed to a mouse model of Alzheimer's disease (Supplementary Box 1).
At a histological level this means that all germ cells within a particular cross-section of a mouse tubule are at the same stage; whereas a cross-section of a human tubule contains several stages.
From a genetic standpoint, an attractive approach would be to study the progeny of Tg2576 AD mice crossed to a mouse that could be induced to express SOD-2 on demand (for example a mouse that overexpresses SOD-2 in response to tetracycline treatment - tet-on-SOD-2).
Cross section of a mouse bearing a subcutaneous tumor.
Fabry-Rag mice are a stable cross of a Fabry mouse and a Rag-1 mouse [40] to generate an immune-deficient strain of mouse that accumulates GL-3 and can receive repeat doses of recombinant human α-galactosidase without developing a humoral immune response.
Wolf Cocklin @wolfcat on Tony Abbott's decision to "suspend" maritime management plans introduced by the Labor government to allow fishers back into those areas: Mouse brain What thoughts cross the mind of a mouse?
We recently reported that a new mouse model of AD, generated from a cross of a common AD mouse model (3xTgAD) with a mouse heterozygous for the BER enzyme DNA polymerase β (Polβ), had aggravated features of AD relative to the 3xTgAD mouse [ 15]: the reduction in Polβ in these 3xTg/Polβ mice induced neuronal dysfunction, cell death, and impaired memory and synaptic plasticity.
Crossing of mice expressing an exon E1-floxed PPR allele [25] with mice that express Cre recombinase under the control of the T cell-specific promoter Lck [26], led to the generation of mice with disrupted PPR gene in T cells (PPRT cells −/− mice), and intact PPR expression in other cells.
To inhibit Notch signaling in the pancreas epithelium, we crossed a mouse model of pancreatic cancer based on pancreas-specific expression of mutant Kras with a transgenic mouse that conditionally expresses a dominant negative form of the Mastermind-like 1 gene.
The good storage stability, high magnetic content (88.7%), high saturation magnetizations and superparamagnetic behavior suggested their great potentials as MRI contrast agents, which were confirmed by their measurements of r2 and coronal image of the crossing of mouse kidney.
