In the second part of the study, we prospectively cross-validated this scoring system in a series of 90 adnexal masses in 86 patients between July 2001 and March 2002.
Because of nonstationarity, it is unclear how one can cross-validate this parameter, so the minimal distance needs to be selected a priori for each application on a representative data segment, and experience shows that performance changes smoothly around the optimum [8].
At least 55 genes were found to peak in early G1; however, this is likely to be an underestimate as we could not directly cross-validate this time-point with a specific corresponding time-point from the starve-synch data.
Second, to cross-validate this maximum fidelity, we added to the sample (Supporting Information, Table S2, 10th entry) random errors in SA and SA* at increasing rates eA+eA*, and observed that above emax≈0.65 the error bound pe− approached one (Supporting Information, Fig. S1).
For future studies, it would be beneficial to cross-validate this with semi-structured interviews, as soon as those have been validated in the majority of countries.
To cross-validate this approach, the same 33 items were subjected to confirmatory factor analysis in validation sample B. Nearly half of the loadings on the single factor dropped below 0.4 and the proportion of residual correlations rres>|.20| increased from 5.1%to12.0%0%.
Since this filter is not aggressive, we do not cross validate this step even though it was not agnostic to outcome.
Briefly, cross validating a model is done by first splitting the data set into a number of equally sized partitions.
In the absence of an independent cohort our derived models were based on DXA body composition parameters and cross validated [ 2]; this may explain the improved agreement from the derived models with DXA, compared with the BIA8 manufacturers' estimates.
The remaining data set is used to build and cross-validate the prediction model for this 10-gene signature.
The purpose of this study was to cross-validate these shorter versions in two new populations.
