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This complicates cross trial comparison and was our rationale to use median values as 'cut-off' for the analyses.
Therefore, the individual HR of the CROSS trial and the TROG trial, excluding SCC, were calculated separately from the data given by the original article, and the results were 0.73 (95% CI 0.54-1.00) in the CROSS trial and 1.02 (95% CI 0.72-1.44) in the TROG trial.
Contrary to this, the CROSS trial found no significant increase in peri-operative mortality, which probably reflects the use of patient selection and improvement in surgical care and radiotherapy delivery over time.
The CROSS trial has regenerated enthusiasm for neoadjuvant CRT trials in the UK and a national oesophageal workshop held in 2012 identified neo-adjuvant CRT as a key area of future research within the UK [ 7].
The landscape of neo-adjuvant CRT has recently changed with the reporting of the CROSS trial [ 6] which showed no increase in peri-operative mortality and a near-doubling of median survival compared to surgery alone.
These data are encouraging, but as patients were only enrolled after completion of the radiotherapy, cross trial comparisons with the landmark trial by Stupp et al. [1] cannot be made.
Similar(48)
Because there are limited head-to-head data comparing antiretroviral combinations, physicians are tempted to rely on cross-trial comparisons to evaluate the relative efficacy of HIV drugs.
However, differences in patient populations, comparators, and selection and/or definition of secondary endpoints make it difficult to draw direct cross-trial comparisons.
In order to further activate the therapeutic progress against acute myeloid leukemia (AML), we recently proposed cross-trial networking based on general upfront randomization and a common standard arm.
This makes cross-trial comparisons difficult [ 30– 30].
This implies that cross-trial variation in this early sensory-evoked component occurred largely orthogonal to cross-trial variation in the later (putatively decision-related) component.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com