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It has been reported that most beta-lactam tolerant strains of S.aureus show cross tolerance to vancomycin and teicoplanin [ 23].
Not all paradigms that produce antinociceptive tolerance produce cross tolerance to multiple opioid drugs [28] [31].
This analgesic effect can be blocked by naloxone and shows cross tolerance to morphine [ 44].
This benefit of cross tolerance reduces the potential for negative outcomes.
This is done in order to negate an "incomplete cross tolerance" among opioids.
However, cross tolerance has also been described, in which exposure to one ligand inhibits downstream signalling from multiple receptors without affecting their expression 36, 40.
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The evidence theoretically clarifies the mystery of why an alcoholic develops what is called a cross-tolerance to such chemically unrelated substances as halothane and other anesthetics.
Tolerance and cross-tolerance were assessed by quantification of the thermally induced tail-flick response.
It was previously found that ethanol dependence conferred cross-tolerance to the behaviorally activating effects of dizocilpine.
The tolerance builds so quickly and there's a cross-tolerance between all the serotonergic hallucinogens that the classic view is you don't dose more than every two months".
Another rat study, from Biological Psychiatry in 2004, also found that THC exposure induced "cross-tolerance" that could increase later usage of cocaine, morphine, and amphetamine.
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