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Studies of the interaction of light with animal tissues have shown that light above 600 nm tends to cross tissues with minimum absorption and scattering, whereas blue/green light is more attenuated [21], [35].
The ability of S. iniae to cross tissues through plasminogen activation is facilitated by α-enolase (35 ), which is also a known contributory factor to the virulence of GAS (36 ).
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Nanoparticles hitchhiking on monocytes readily cross tissue transport barriers and allow delivery to brain, tumors and lungs for targeted drug delivery and immunotherapy.
Expression of the seven candidate reference genes varied across all tissue types tested, indicating that none of the genes could suitably serve as reference genes for cross tissue comparisons.
But it found more cross tissue type clusters.
It needs to be noted that invadopodia also appear in some normal cells such as immune cells when they have to cross tissue boundaries.
Torres, J. M. et al. Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait.
Epigenome-wide cross-tissue predictive modeling and comparison of cord blood and placental methylation in a birth cohort.
Motivated by the observation of Gayvert et al.15 and others that the general target tissue expression profile is associated with specific toxicities, we used expression breadth annotations from a cross-tissue analysis of the Human Protein Atlas65.
Our cross-tissue analysis allowed us to detect pan-cancer characteristics, and we suggest that stromal changes in NAT represent an emerging hallmark of cancer that may be essential for tumorigenesis and/or tumor progression.
Other confounders include variables that have been previously linked to side effects: properties of the protein such as its cross-tissue expression pattern15, properties of the gene such as evolutionary constraint37 and corresponding intolerance of population genetic variation27, or properties of the drug such as modality or delivery route.
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