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When the analysis is restricted to the two low risk of bias trials which had prespecified blood transfusion as an outcome, the z-curve does not cross the monitoring boundary and the heterogeneity-adjusted information size is not achieved.
As a result, a future RCT including the projected 3,800 patients will, in some situations, not be enough to make the meta-analysis conclusive (ie, cross the monitoring boundaries for moderate evidence).
In technical terms, we calculated that a new trial showing a 5% control group incidence rate and a 25% relative risk reduction would have to include 9000 patients for the meta-analysis to cross the monitoring boundaries for strong evidence (ie, the monitoring boundaries based on the information size for strong evidence, 19,920 patients).
In technical terms, we calculated that a new trial showing a 5% control group incidence rate and a 25% relative risk reduction would have to include 3,800 patients for the meta-analysis to cross the monitoring boundaries for moderate evidence (ie, the monitoring boundaries based on the information size for moderate evidence, 10,508 patients).
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Breakthrough of inorganic species was observed when the injection slug crossed the monitoring transect.
Mass loading for all the monitored gasoline compounds reduced by 46to86%6% as the inorganic slug crossed the monitoring transect.
The z-curve crosses the monitoring boundary after the 22nd high-quality trial published in November 2008.
The z-curve crosses the monitoring boundary before the heterogeneity-adjusted information size is achieved when the 28th trial was published in March 2001.
The sequential analysis revealed that the cumulative Z-curve crossed the monitoring boundary, which confirmed the overall result after adjusting for multiple testing.
More specifically, changes in BMI in kg·m−2 crossed the monitoring boundary for a type 1 error in 2010 and have remained stable thereafter.
Trial sequential meta-analysis showed that changes in BMI crossed the monitoring boundary for a type 1 error in 2010, remaining stable thereafter.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com