The objectives of this study were to examine the dose-response characteristics of acute and chronic MDMA administration in rats and to determine whether MDMA elicits behavioral sensitization and whether it cross-sensitizes with amphetamine and methylphenidate.
This was done to determine whether MDMA can elicit behavioral sensitization as well as to cross-sensitize with other psychostimulants.
Evidence of a reciprocal relationship between 5-HT2 receptors and corticotrophin releasing factor (63) raises the possibility that these systems may also cross-sensitize their responses to stress exposure.
Chemically-unrelated agents, e.g., stress and amphetamine or cocaine [ 209], sucrose and stimulant drugs or alcohol [ 210, 211], formaldehyde and cocaine [ 212], stress and morphine [ 213], stress and diazepam [ 214], can all cross-sensitize with one another.
However, a possible explanation supporting the failure of MDMA to cross sensitize to other stimulants could be given by the presence of evidence suggesting that the primary course of action of MDMA is through 5-HT releasing neurons.
The fact that a proinflammatory chemokine, by interacting with its receptor on small-diameter neurons, sensitizes TRPV1 reveals a novel mechanism of receptor cross-sensitization that may contribute to hyperalgesia during inflammation.
MDMA sensitized to its own locomotor activating effects but did not elicit any cross-sensitization with amphetamine or methylphenidate.
This type of apple allergy is caused by cross reactivity of IgE antibodies against the major and sensitizing birch pollen allergen Bet v 1 with Mal d 1, the major allergen of apple.
Also, maternal IgE can cross foetal membranes and sensitize immune cells of the foetus to allergens [ 31].
Finally, siRNA-mediated silencing of ERCC1 (excision repair cross complementing group 1) sensitized human colorectal cancer cells to oxaliplatin-induced cell death [ 52].
NPPOC derivatives are themselves relatively inefficient in two-photon deprotections; however, in the presence of sensitizers (section 8) (it has been shown by Wöll and co-workers that NPPOC can be sensitized), the cross section can reach useful levels for several applications.
