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Moreover, prior psychological states and psychiatric comorbidities can confer a heightened risk for pain chronicity due to processes such as cross sensitization, where exposure to stress in the past results in greater sensitivity to other seemingly unrelated stimuli[2].
Furthermore, recent studies of certain food allergies suggest that IgE antibodies specific to carbohydrate moieties on glycoproteins may be involved in cross sensitization.
On the other hand, Ara h 8, a Bet v 1 homologue, is a pathogenesis-related protein 10 (PR-10) implicated in mechanisms of cross sensitization between pollens and foods [ 13], and the nonspecific lipid transfer protein (nsLTP) Ara h 9 is an allergen prevalent in the Mediterranean area [ 14].
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One animal experiment found that 5-time nicotine administrations at 3-day intervals developed a significant locomotor stimulant effect and caused an enhanced sensitivity (cross-sensitization) to MA, although nicotine had no effect at first administration [ 49].
The fact that a proinflammatory chemokine, by interacting with its receptor on small-diameter neurons, sensitizes TRPV1 reveals a novel mechanism of receptor cross-sensitization that may contribute to hyperalgesia during inflammation.
MDMA sensitized to its own locomotor activating effects but did not elicit any cross-sensitization with amphetamine or methylphenidate.
Repeated exposure to inhaled toluene induces behavioral and neurochemical cross-sensitization to cocaine in rats.
Amphetamine-sensitised rats show sugar-induced hyperactivity (cross-sensitization) and sugar hyperphagia.
Moreover, cross-sensitization between cocaine and TRH has also been demonstrated.
Other druglike properties of sugar include (but are not limited to) cross-sensitization, cross-tolerance, cross-dependence, reward, opioid effects and other neurochemical changes in the brain.
Wuo-Silva R, Fukushiro DF, Borcoi AR, Fernandes HA, Procopio-Souza R, Hollais AW et al. Addictive potential of modafinil and cross-sensitization with cocaine: a pre-clinical study.
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