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In the beginning there was "double dipping", which became "second screening" which, in turn, became "sequential cross screening".
Kinase cross screening identified VER-150548 as a potent inhibitor of Aurora A (IC50 101 nM) and Aurora B (IC50 38 nM) kinases (Table 1).
Using fragment screening, structure guided drug design and kinase cross screening we have identified VER-150548, a potent small molecule inhibitor of both Chk1 and Chk2, and Aurora A and Aurora B kinases.
Fragment screening, structure guided design, and kinase cross screening resulted in the identification of a novel, potent small molecule kinase inhibitor (VER-150548) of Chk1 and Chk2 kinases with IC50s of 35 and 34 nM as well as the Aurora A and Aurora B kinases with IC50s of 101 and 38 nM.
A number of large cross screening panels have been developed recently that allow extensive profiling of kinase inhibitors [5,32 34].
There are other confounding trends that could be tested for, for example targets-per-paper (i.e. < cross-screening over the years might correlate with apparent promiscuity <) and orthologue vs paralogoue cross screening (i.e. if the average human:rodent ratio changes over time for the low confidence set).
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There's Drawbridge for Cross Screen Marketing, which allows companies to run mobile ad campaigns that retarget their web visitors.
Bill, an innovator in the space has also worked at Napster and IBM (creating the IBM Internet Group) and has driven improvement in products, cross screen platforms and operational processes at a global level.
Data is the link that is making cross-screen planning possible.
Phrases like "scalable marketing initiatives" and "complete cross-screen measurement" came out of executive mouths.
Furthermore, with the average household now owning 7.4 connected devices, HTML5 is the perfect solution to running cross-screen campaigns.
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CEO of Professional Science Editing for Scientists @ prosciediting.com