Table 4 shows results from cross prediction using mast observed data.
Even with multiple mechanisms leading to toxicity, each of which coming with a different pharmacophore, the true actives are expected to be more like each other than random compounds and cross prediction should be easier.
An inter-species cross prediction showed that T4SEpre_Joint could recall most known effectors from a variety of species.
The SNP-involved MREs predicted by MirSNP's miRanda algorithm were subjected to cross-prediction with two additional miRNA target site prediction algorithms namely TargetScanHuman 6.2 [37] and RNAhybrid [38,39].
The results of the cross-predictions suggest that although most of the clusters were not well-predicted in macaque (Table 2; Macaque column; membership of all DE genes found in Additional File 4), clusters 8, and 10, show statistically significant correlations, 0.68 and 0.72, respectively (Table 2), versus randomly permuted clusters.
The paper authored by G. Wang et al. shows how AR models, which are based on minimizing a new cost function, mean-square cross-prediction error, are useful to extract the atrial activity signal from ECG registers.
a Xpred scores from Calu-3 model cross-predictions in macaque and mouse.
To account for this, the MREs were subjected to consistent cross-prediction by TargetScanHuman 6.2 [36,37] and RNAhybrid 2.1 [38,39].
To further process the similarity analyses between both endpoints, we proposed cross-prediction between these two endpoints.
We tested this hypothesis by cross-prediction with two minimized signatures, i.e. signatures for endpoint D were used for prediction tasks of endpoint E and vice versa.
Therefore, this cross-prediction approach covers the multiple features shown to be informative for MRE identification and thus reduces false positives.
