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Line cross analyses typically begin with two inbred parental lines that are crossed to produce an F1 generation.
When RIL are used in line cross analyses, scaling tests can be constructed for non-additive genetic effects with far more precision than traditional methods of estimation.
Line cross analyses are primarily carried out using frameworks based on the F2 model of Cockerham [39] or on the F-infinity model of Hayman and Mather [40].
In addition, the database was extensively embedded into the currently available genomics repositories supporting advanced searches and cross analyses with other databases.
To determine the mode of gene action affecting the expression of phenotypic variation in fitness-related traits, we used line cross analyses, specifically joint scaling tests, as described in Chapter 9 of Lynch and Walsh [ 71].
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The experimental cross analysed here was intended to associate RAD alleles with chromosomes, and in particular, identify sequenced markers on the chromosome encoding spinosad resistance.
We analysed the case studies thematically and used rigorous multi-dimensional and multi-disciplinary interpretive validation techniques to cross analyse findings.
Results of line-cross analyses for hybrid traits.
Line-cross analyses (Lynch and Walsh 1998) were performed on data for every stage of the experiment (initial conditions, food limitation period, compensatory period) to assess the genetic basis for length, mass, routine and CG rates, parr maturity and morphology.
MAPfastR provides functionality for F2 crosses and backcrosses under the assumption that different QTL alleles are fixed in the founder lines (Crooks et al. 2011), line-cross analyses allowing for within-line segregation (flexible interclass analysis [FIA]; Rönnegård et al. 2008), and tests for epistatic interactions (Carlborg and Andersson 2002).
Line-cross analyses showed that a simple additive genetic model was sufficient to explain the length, mass, routine growth rates, CG rates, initial and final morphologies and incidence of parr maturity values for each cross for every measurement period (Fig. 5, Table S9).
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