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Dengue vaccine development is considered a global public health priority, but the antibody-dependent enhancement (ADE) issues have critically restricted vaccine development.
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Methanol crossover critically restricts the practical application of direct methanol fuel cells (DMFCs).
The poor cycling stability and inferior rate capability of the cathodes critically restrict the application of sodium ion batteries (SIBs).
We confirm that bisphosphonate treatments can increase non-enzymatic collagen cross-linking at molecular scales, which critically restricts plasticity associated with fibrillar sliding, and hence intrinsic toughening, at nanoscales.
We show that R561 is important for kinesin-3 function and provide evidence that Unc-104 critically restricts neuromuscular junction (NMJ) growth during larval development.
Present methods to detect congenital heart defects are limited to time frames proximal to phenotype onset, which critically restricts opportunities for curative or palliative interventions.
The central rock-rat (Zyzomys pedunculatus) is critically endangered and restricted to rugged range country in central Australia.
Even the greater bamboo lemur, a critically endangered species restricted to a small portion of the south-central eastern rainforest, has undergone significant range contraction since the mid-Holocene, with subfossil remains from Ankarana Massif in the far north of Madagascar dating to 2565 BCE ± 70 years.
The focus of this study is a comprehensive assessment of the evolutionary histories of the broadly distributed population of western lowland gorillas (G. g. gorilla) and the range restricted, Critically Endangered Cross River gorillas (G. g. diehli).
This is especially important now, with Greek credit and liquidity severely restricted, most critically in its vital small-business sector.
Critically however, when we restricted our analysis of results to studies with adequate methods, the pattern of an increase in mortality associated with RBCT remained unchanged (table 4).
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