Sentence examples for critically reduce from inspiring English sources

The H275Y mutation in the neuraminidase (NA) gene (H274Y in N2 numbering), first described in 2000 [10], is the most frequent mutation associated with oseltamivir-resistance in the N1 subtype, but it had long been thought to critically reduce viral fitness [11].

Loss of both APP and APLP2, but not of either protein alone, might critically reduce this trans-synaptic interaction, resulting in aberrant apposition of nerve terminals and AChR clusters.

This served to critically reduce maternal morbidity and mortality rates, increase integrated management of childhood illness and reduce under-5 mortality; all health indicators that are a critical reflection of the state of health and development for low- and middle-income countries.

Most AEDs are such a weak substrate of P-gp, that, in principle, the constitutive expression of that protein on BBB is not able to reduce the inflow of AEDs in a clinically important way [ 41]; however, the inborn or acquired excessive expression P-gp in BBB may critically reduce the penetration of AEDs to the brain, resulting in resistance to many AEDs [ 41– 41].

A conventional furnace heat treatment critically reduces hardness and fracture toughness after a certain temperature.

The condition for critically reduces to the analysis of the eigenvalues of the Jacobian matrix.

Furthermore, the administration of CAPE critically reduced the expression levels of Hif-1a, NF-kB and PDGF molecules in the lung of MCT-induced PAH rats.

Additionally, in the absence of PCD, 7-substituted pterin is formed and competes with the natural cofactor tetrahydropterin for PAH, leading to a critically reduced hydroxylation rate (Davis et al. 1991).

We describe two patients with normally functioning stented aortic bioprostheses with supra-annular design (EPIC SUPRA and PERIMOUNT MAGNA), wherein very high trans-prosthetic gradients and critically reduced estimated effective valve orifice areas in presence of normal aortic size were consistently recorded over long periods of follow-up.

This model specifically posits that schizophrenia arises from critically reduced synaptic connectivity as a result of developmental disturbances of synaptogenesis and supports the neurodevelopmental theory.

Transient transfection of PAEC with a plasmid carrying the antisense PCMT significantly lowers the activity of the endogenous methyltransferase, by critically reducing its expression.