The painkillers – co-codamol, a mixture of paracetamol and codeine – tend to work less effectively over time but, critically, make you more constipated!
These studies should provide more biological information than the empirical studies of yesteryear and we should view the results critically, making certain that whatever quantitative benefits we observe are clinically justified.
All the authors have read the draft critically, have made contributions, and have approved the final text.
JW has revised the manuscript critically and made substantial contributions to the manuscript CB, SH and AJ revised the manuscript critically and made substantial contributions to conception and design of the present study, and acquisition of data.
KSK conceptualized and designed the study, reviewed the manuscript critically and made changes in the content.
SK has been revised the manuscript critically and made substantial contributions to acquisition of data in the FINRISK Senior Survey.
FLL, MGG, CM, FL, EP, MCJMS and LGM reviewed the manuscript draft critically and made important contributions to its revision.
HJS prepared the first draft of this manuscript, and GG and EAA revised it critically and made suggestions for improvements.
MH, JE, EP-L, SP, and JL reviewed the manuscript draft critically and made important contributions to its revision.
JH has been revised the manuscript critically and made substantial contributions to acquisition of data in the HUNT Study.
