Delivery in severe and critically infected women after 37 weeks' of gestation had improved neonatal outcomes compared to similar patients who delivered before 37 weeks of gestation.
The mortality rate for severe or critically infected pregnant women in our study was 20%, similar to what was reported in Canada, Mexico, and New Zealand [ 22- 25], but higher than in France (8% death in ICU-hospitalized pregnancy women) [ 4].
See related research by Parnell et al., http://ccforum.com/content/16/4/R157 In a recent issue of Critical Care, Parnell and colleagues examined host gene expression changes in whole blood from critically ill patients infected with pandemic H1N1 influenza A infection [ 1].
Little is known about kidney outcomes and dialytic requirements in critically ill patients infected with pandemic H1N1.
This notion is supported by one randomized, clinical trial [87] and two retrospective, observational studies [45, 96], which were conducted in critically ill patients infected with gram-negative organisms.
The positive results from observational studies, especially in the face of increasing antibiotic resistance, serve to justify the imperative need to conduct a large-scale, well-designed, multicentre RCT involving critically ill patients infected with high minimum inhibitory concentration pathogens to clearly substantiate this benefit.
Interestingly, convalescent plasma from this same patient who had donated the blood for generating hAbs a few weeks earlier was used to transfuse a critically ill patient infected with a genetically similar H5N1 virus; the passive immunotherapy recipient subsequently recovered [32], [33].
A large, multicenter RCT with critically ill patients infected with MDRGNs is needed.
Proportional changes of the susceptible population could explain the observed differences in the profile of critically ill patients infected and the increased severity at admission to ICU.
This notion is supported by one randomized, clinical trial [ 87] and two retrospective, observational studies [ 45, 96], which were conducted in critically ill patients infected with gram-negative organisms.
The expression levels of JAK2, CASP3, IL-10, and MX1 significantly increased, whereas TP53 and TGFBR1 significantly decreased in PBMCs from critically ill patients infected with H1N1 influenza virus than that from healthy controls.
