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The effects of fragmentation have been shown to critically impair the ability of an ecosystem to provide viable habitat through decreased area, increased isolation and edges [39].
Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery.
The possible presence of M3R in the vasculature, reduced blood flow responses and salivary secretion to muscarinic receptor activation support the notion that M3R autoantibodies present in NOD mice might critically impair fluid transport required for salivation.
The analysis of AM alterations related to cancer, based on a network view, has pinpointed the critical role of the hubs, the structurally and functionally most important nodes of the network, which could critically impair network's stability and accordingly the physiologic status of the cell [ 117].
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A systemic-risk regulator could also assume the important function, currently lacking, of a sort of F.D.I.C. for nonbank financial firms, with authority to seize and restructure critically impaired firms before they threaten the broader system.
So last month, in an announcement that could have come straight out of a Dan Brown novel, Icann announced that the internet would be protected by seven "guardians" on three different continents whose job would be to reboot the internet if the DNS system was ever critically impaired.
However, its physicochemical instability critically impairs its dosage form design, evaluation and administration.
Similarly, experimental animal models attempting to demonstrate impaired cellular oxidative bioenergetics or abnormal lactate/pyruvate ratios have not demonstrated evidence of critically impaired oxidative metabolism during sepsis [44 47].
This critically impairs our ability to determine appropriate topographical cues to be included in implantable devices that can be used to maintain or improve endothelial cell function in vivo.
Surprisingly, expression of many genes related to host defense were critically impaired upon RU486 treatment, a mechanism that could explain unusual bacterial infections in individuals taking this compound as abortion pill and the beneficial effects of an acute therapy with GCs.
In this concept, patients with a critically impaired pulmonary gas exchange remain candidates for ECMO.
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