Sentence examples for critical trigger of from inspiring English sources
Thus, rafts behave as recruitment platforms to facilitate and potentiate downstream signaling events, with Fas functioning as a critical trigger of the apoptotic process.
ROS have been implicated as a critical trigger of activation of autophagy [ 14, 43].
These data provide robust confirmation of the hypothesis that cytosolic Ca2+ overload is a critical trigger of acute pancreatitis.
On this basis, attention over the last two decades has focused largely on conditions that convert XDH to XO as the critical trigger of radical generation.
Telomere shortening, a consequence of repeated cycles of DNA replication is thought to be a critical trigger of senescence [ 6, 7] which also involves activation of two major tumor suppressor pathways, p53 and Rb [ 2, 8, 9].
Associated with the idea that a larger ICa current was necessary to trigger CICR in fish cardiomyocytes, we further showed that the density of ICa was a critical trigger of SR Ca2+ release (Fig. 7).
Our previous study confirmed that ER stress was one of the critical triggers of cardiomyocyte apoptosis in DCM [ 11], which was responsible for the myocardial cell loss in DCM [ 11, 12].
In this investigation we report that high bilirubin levels present during liver disease were identified as critical triggers of suicidal erythrocyte death and anemia in vitro and in vivo.
It is possible that Matrigel is required for the engraftment of H2BGFP+/CD24+/CD29lo cells in vivo, but based on our data, we conclude that pregnancy is still the critical trigger for development of mammary structures able to pass the threshold of detection in most outgrowths.
These observations suggest that phosphorylation of TFIIB serine 65 is important for the formation of gene loops and potentially forms a critical trigger for the initiation of transcription.
IAVs first interact with the host through epithelial cells, and the viral RNA containing a 5′-triphosphate group is thought to be the critical trigger for activation of effective innate immunity via pattern recognition receptors-dependent signaling pathways.
