Thus, analyzing basal deposits at the ultrastructural level and understanding the ultrastructural pathologic differences between various mouse AMD models are critical to comprehending the significance of research findings and response to possible therapeutic options for dry AMD.
First, the most powerful experimental systems for studying development are set up to minimize variation that may be critical to comprehending how evolutionary processes occur in nature.
This will be critical to better comprehend the generalities of the vulnerability of marine benthic communities under ongoing and predicted global environmental changes.
As select ECM components are known to regulate specific stem-cell functions, a robust characterization of cell-derived ECM proteomic composition is critical to better comprehend the role of the ECM in directing cellular processes.
In the face of leishmaniasis distribution in Brazil, its spread to important cities and the overlap with HIV-infected individuals, it is critical to further comprehend the sophisticated interplays among Leishmania, HIV and macrophages.
Despite all these beneficial effects, the HIV PIs induced an increase in the expression of cysteine peptidase b (cpb) and the metallopeptidase gp63, two well-known virulence factors expressed by Leishmania spp. In the face of leishmaniasis/HIV overlap, it is critical to further comprehend the sophisticated interplays among Leishmania, HIV and macrophages.
This information is critical to fully comprehend the content of the PA program in the LIFE Study, an important element of external validity.
In this analysis it was not necessary to perform the selective coding, since we were able to comprehend the critical success factors after the open and axial coding.
The tight links between energy and water in agriculture underscore the importance of co-planning and co-managing these critical resources a goal that is easy to comprehend but hard to achieve.
Therefore, it is critical to ensure that policy makers need to comprehend these varied 'sub-cultures' in order to create suitably differentiated tools to those used in large corporates for use in SMEs [10, 22, 35].
