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Protooncogenes and tumor suppressor genes could be critical targets for carcinogens (Pfeifer and Denissenko, 1998; Hussain and Harris, 1998).
Hence, long AT-islands represent a novel class of critical targets for anticancer drugs.
We found neurons of the central nervous system critical targets for infection by JEV, which directly causes lethal encephalitis.
Fatigue and other treatment-related symptoms (e.g., sleep disturbance) are critical targets for improving quality of life in patients undergoing chemotherapy.
For the design of novel antifungal agents, it is necessary to comprehend the life cycle, morphology, metabolic pathways, etc. of fungi scientifically and systematically to identify critical targets for antifungal drug design.
The president has set critical targets for cutting U.S. carbon pollution in 2020 and 2025, and strong power plant standards are the centerpiece of that effort.
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Akt has emerged as a critical target for the development of anti-cancer therapies.
Mori, M. et al. Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation.
p27 cells treated with KIS siRNA grow and progress to S/G(2 )similar to control treated cells, implicating p27(Kip1) as the critical target for KIS.
The protease enzyme pathway is the critical target for drug design due to its significance in the replication, survival and other cellular activities of dengue virus.
Candida glabrata is a lethal fungal pathogen resistant to many antifungal agents and has emerged as a critical target for drug discovery.
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