Sentence examples for critical substrate of from inspiring English sources

MLKL is the critical substrate of RIP3 kinase in necroptosis-signaling pathway.15 Therefore, we test whether MLKL participated in matrine-induced necroptosis.

This indicated that Smc3 is the only critical substrate of Eco1.

Our study uncovers for the first time that BKM120 can also modulate NF- κB, another critical substrate of AKT.

The critical substrate of Eco1 is Smc3, which is acetylated on two residues K112 and K113 in its NBD (Ben-Shahar et al. 2008; Unal et al. 2008; Zhang et al. 2008; Rowland et al. 2009).

Akt is the most critical substrate of the PI3K and its activation depends on the PI3K-mediated reversible conversion of PtdIns(4,5 P2 to PtdIns 3,4,5 P3.

Finally, we showed that the anti-apoptotic effect of CK2 in human prostate cancer cells depends on Par-4 inhibition, thereby identifying Par-4 as a functionally critical substrate of CK2.

The objective of this study was to investigate the neural basis of these effects in critical substrates of IC--right inferior frontal cortex (rIFC) and presupplementary motor area (pre-SMA).

One of the critical substrates of the G1-specific cdk cyclin complexes is the retinoblastoma (pRb)–E2F protein complex resulting in the release of E2F upon phosphorylation (Sherr, 2001).

Two critical substrates of ZAP70, LAT and SLP76, are then activated to organize formation of the proximal signalosome, which is responsible for transducing a series of kinase cascades that in turn lead to the release of secondary messengers and activation of RAS and mitogen-activated protein kinase (MAPK) pathways.

Arkadia appears to effectively enhance TGF- β signaling through simultaneous downregulation of two distinct types of negative regulators, namely, Smad7 and SnoN, which are critical substrates of Arkadia and may play an important role in determining the intensity of TGF- β family signaling in target cells [ 17].

Following speculation that mutations in humans FoxP2 might be associated with the evolution of language, a number of studies have screened FoxP2 in vertebrate species that show evidence of vocal learning, which is widely considered to be a critical substrate for the evolution of human language.