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Critical pathways are among the key tools used to achieve consistently excellent outcomes at these institutions.
Clinical or critical pathways are a useful tool in the continuous quality improvement.
Critical pathways are predefined protocols that define the crucial steps in evaluating and treating a clinical problem to improve quality of patient care, reduce variability and enhance efficiency.
Once critical pathways are identified, investigators can work on means to inhibit those pathways leading to disease modifying therapy.
Care pathways, also known as clinical pathways or critical pathways, are used worldwide for a variety of patient groups [ 5- 13].
All of these critical pathways are dependent not only on enzymes but also on substrates and cofactors, a few of which are only available at the right concentration when the dietary intake of key minerals and vitamins is adequate [ 44].
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Typically, activation of critical pathways is accompanied by subsequent activation of negative feedback loops reducing pathway activity.
Most variations on critical pathways were attributed to level of detail and number of days to be followed.
The identity and prevalence of individual mutations that drive critical pathways is variable from tumor to tumor.
Activation and subsequent deregulation of these critical pathways is a plausible cause for the permissive tumorigenic environment that is the hallmark of NF1-haploinsufficiency.
These responses are regulated or affected by DNA damage responsive (DDR) pathways, and one of these critical pathways is the DNA checkpoint pathway, which is a signaling cascade associated with intensive phosphorylation (Carr 2002).
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