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This way critical pairs ( left({I}_{1,0},sqrt{J_{2,0}}right) ) are obtained.
An interesting phenomenon of a zigzag pattern of the critical pairs is discovered and studied numerically.
Four critical pairs giving partially overlapped peaks are identified and multiresponse optimisation is carried out by analysing the surface plot of a global resolution defined as the average of the resolutions of the critical pairs.
Twelve responses, involving quantitation-related items, such as recovery of Rg1 and Rb1, and qualitative items, such as resolution (Rs), theoretical plate number (N), relative retention time (RRT) of two critical pairs, are measured.
The verification of confluence makes use of a verified adaptation of Nipkow's higher-order critical pairs lemma to the forms of rewrite rules required for the statement of the λσβ0-calculus.
Following step by step AQbD methodology, firstly as critical process parameters (CPPs) temperature, starting content of aqueous phase and duration of linear gradient are recognized, and as critical quality attributes (CQAs) separation criterion S of critical pairs of substances are investigated.
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The O'Shaughnessy model also uses a critical pair of variables: the price/sales ratio, and relative strength.
By optimizing the separation with gradients of increasing complexity, acceptable resolution was possible, being glycine/threonine the critical pair.
The temperature selection of 35°C was optimized so as to attain maximum separation between the critical pair which is Imp-D and lafutidine.
The critical quality attributes (CQAs), i.e. the separation (S) between peaks of the most critical pair, and the analysis time were the criteria considered to assess the quality of the separation.
For example, ENTH, ANTH, and FYVE domains have been found to possess a critical pair of histidines in their PIP-binding sites, known as a 'histidine switch'.
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