Sentence examples for critical mutation from inspiring English sources
The different WP2 strains all carry the same AT base pair at the critical mutation site within the trpE gene.
Using this definition, we suggest two approximate formulas to estimate the critical mutation rate after which the quasispecies delocalization occurs.
The last estimate stresses the fact that the inverse dependence of the critical mutation rate on the sequence length is not a generally valid fact.
Furthermore, it is shown that space, which involves a lower critical mutation rate, broadens the conditions at which the survival-of-the-flattest may occur.
For the specific case of a single peaked landscape we also find lower and upper bounds on ¯¯¯w q), which are used to estimate the critical mutation rate, after which the distribution of the types of individuals in the population becomes almost uniform.
The use of a disulphide bridge (I117C5→4, numbering according to wt avidin) combined with a critical mutation (V115H6→5) in the interface between subunits [19] made it possible to develop dcAvds with defined quaternary structures [20].
Neither mutational nor distance measurements appear to identify kinetically critical mutations quantitatively, or to separate N-glycan and sialic acid interactions.
This paradigm indicates that specific, critical mutations produce abnormal cell proliferation leading to cancer, rather than ER-mediated abnormal cell proliferation that generates random mutations [1, 6 10].
Possible errors in the repair of these sites can lead to the critical mutations initiating many common human cancers [63, 64].
Critical mutations and distorted redox signaling pathways orchestrate pathologic events inside cancer cells, resulting in resistance to stress and death signals, aberrant proliferation and efficient repair mechanisms.
The specificity of the critical mutations is the result of the preliminary intercalating physical complex between estrogen and DNA that occurs before formation of the covalent bond between them.
