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H3K56ac is a critical modification for nucleosome assembly in yeast35,36 and the S57 residue in H3.3 is replaced by alanine in H3mm7.
Our results provide evidence that p300/CBP-mediated acetylation may be a universal and critical modification for p53 function.
In addition to the induction of its protein synthesis, phosphorylation is a critical posttranslational modification for Atg32 to become active for mitophagy.
This form of protein fatty acylation is emerging as a critical regulatory modification for multiple aspects of cellular interactions and signaling.
The interaction between HA- CD44 is critical for modification of this communication axis during CCs expansion [ 101] and relatively higher expression of these molecules in cultured CCs is consistent with the notion that HA- CD44 interactive effect is vital for oocyte maturation [ 100].
In this study, a search was begun for genetic modifications critical for high-level antibiotic production.
Thus, our study provides the initial steps toward understanding the role of the proteasome in regulating histone modifications critical for synaptic plasticity.
That additional sites of modifications critical for normal cellular function remain to be identified thereby necessitates further investigations directed toward elucidating a complete atlas of histone PTMs.
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To address whether lapatinib can induce NF-κB activation in both HER2-positive and HER2-negative breast cancer cells, its effect on p65 Ser536 phosphorylation, a critical IKK complex-mediated modification for NF-κB activity [ 25], was examined.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com