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The sensitivity of the epigenetic system to environmental factors occurs primarily during the period of developmental plasticity because this is the time when epigenetic marks undergo critical modifications [ 5].
Here, the following two critical modifications have been made to the previously developed numerical method [24].
PRiC, J-LM, WC, EJ, and MF gave critical modifications to the paper.
The authors say that "critical modifications in terrestrial communities occurred during the Permian period as an increasing variety of herbivorous tetrapods and their predators evolved.
Philip Johnson's Water Garden in Fort Worth, TX, Texas reopened in 2007 after critical modifications were made making the park safe while maintaining the original design intent.
The Evidence: This is one of the most critical modifications in the treatment of bipolarity, where sleep dysregulation frequently precipitates a relapse.
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This critical modification allows the enzymes to bind to specific receptors on the membrane of the Golgi, which then directs them into vesicles leading to a lysosome rather than a secretory vesicle.
Smoothing elastoplastic stress strain curves obtained by a critical modification of conventional models.
Proteolysis is a critical modification leading to alteration of protein function with important outcomes in many biological processes.
Knockout of Suv39h1 and Suv39h2 in mouse results in widespread genomic instability and increased incidence of lymphomas, suggesting that 3MeH3K9 is a critical modification to maintain chromosomal environments [2].
Here we now report about a critical modification of the MTT assay, which allows assessment of organoid survival using both qualitative morphological parameters as well as quantitative colorimetric measurements.
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