Sentence examples for critical localization from inspiring English sources

As a result of its broad substrate specificity and critical localization in excretory and barrier function tissues, P-glycoprotein (P-gp) plays major roles in the pharmacokinetics, safety and efficacy profiles of numerous drugs.

This implies a critical localization of the regulating mechanism or (and) of the target in the cellular regions where endothelial and smooth muscle cells adjoin.

Collectively, these results support a redox-sensing functional role of Brf2 C361, whose critical localization at the Brf2-TBP/DNA ternary interface enables modulation of the assembly of a functional complex.

The relaxation analysis yields a well-posed boundary-value problem for an objective post-critical localization analysis.

In particular, the hardening modulus in shear and the slope of the yield surface in a plot of shear stress versus mean compressive stress are critical to localization predictions.

The transduction and encoding of directional information from an external stimulus is critical for localization of other organisms and environmental cues.

We further show that Rho1 facilitates Dia apical targeting, both by inducing the Dia open conformation, thereby exposing N-terminal domains that are critical for localization, as well as by physically anchoring Dia to the apical surface.

Among them, AtCPK2 has been experimentally confirmed to be myristoylated at the N-terminal Gly residue, and the first ten amino acids of the CPK protein are critical for localization to the ER (endoplasmic reticulum) membrane [ 49].

DOI: http://dx.doi.org/10.7554/eLife.00133.015 To determine whether unc-116 and dendritic MT polarity are critical for localization of dendritic proteins, we analyzed the distribution of several dendritically targeted proteins.

To test whether the nucleotide-bound state of MglA is critical for localization, we generated strains synthesizing YFP MglAG21V or YFP MglAT26/27N at native levels (Supplementary Figure S2) as described for YFP MglA+.

In the region identified to be critical for nuclear localization of MSH6, we identified a single point mutation, S285I, which significantly alters the subcellular localization of MSH6.