Sentence examples for critical initial step from inspiring English sources

"The ambitions and plans agreed at the Paris summit in December 2015 should be regarded as a critical initial step.

The selection of the plant species that offers unique and intrinsic characteristics for achieving a maximum removal of metals is considered a critical initial step.

A critical initial step in pre-mRNA splicing involves recognition of the junction between the 5' exon and intron (the 5' splice site) by the U1 snRNP.

Selection and recruitment of key staff was a critical initial step.

Further trimming of delivered peptides is needed and C-terminal cleavage by a cathepsin appears to be a critical initial step necessary for MHC binding.

This could be a critical initial step that subsequently allows CpG methyl binding proteins to bind to methylated CpGs and actively repress a promoter [ 31].

One of the most critical initial steps is the choice of an appropriate cell source.

This observation has been confirmed in yeast using genetic screens, whereby mutations that affect the critical initial steps of sterol biosynthesis are lethal [ 86].

In general, human mammary cancer cells utilized in xenograft mouse models of breast cancer demonstrate a low propensity to metastasize to bone unless introduced via intra-cardiac injection, which bypasses critical initial steps in the metastatic cascade (for review see [ 13]).

Mcl-1 downregulation was shown to be critical in the initial step of mitochondrial events in UV-induced apoptosis.

The finding and secure geochemical identification of a given tephra layer is a critical but merely an initial step.