Sentence examples for critical in stabilizing from inspiring English sources

The in-frame deletion of codon 116 119 (ANHT) completely abolished the only N-glycosylation consensus site in the KCNJ1 protein (amino acids 117 119), which is critical in stabilizing the open state of the channel.

Semisynthetic phospho- and unphosphorylated PTEN containing four mutations K13A, R14A, R15A, and R161A ('N-mutant') was constructed to test the possibility that these basic residues in the N-terminus, co-localized in the crystal structure and implicated in phospholipid binding, might be critical in stabilizing the closed 4p-PTEN conformation.

Alternatively, it has been proposed that RYR2 mutations in the N-terminal and central regions of the protein weaken interactions between these two domains that are critical in stabilizing the closed state of the channel, resulting in an increased open probability and enhanced spontaneous Ca2+ release during stress-induced SR Ca2+ overload (Ikemoto & Yamamoto, 2000; Tateishi et al, 2009).

Phenol or its derivatives were introduced as a bacteriostatic agent and preservative in insulin preparations; however, it was subsequently realized that phenol was critical in stabilizing the dimer dimer interactions within the hexamer, thereby protracting the action of insulin [ 76, 88, 89].

SAV plays a critical role in stabilizing sediments, removing nutrients from the water, and providing a critical habitat for fish, wading birds, and other wildlife.

The Serratus Anterior (SA) has a critical role in stabilizing the scapula against the thorax.

Our results suggest that the electronic structure alteration via codoping engineering plays a critical role in stabilizing the ferromagnetic orderings.

In the presence of dithiothreitol, the WF146 protease suffered excessive autolysis, indicating that the Cys52-Cys65 disulfide bond played a critical role in stabilizing the WF146 protease against autolysis.

It must be an inclusive process, including all states in the region and beyond that will play a critical role in stabilizing Afghanistan's future, especially those that have suspicions and rivalries with one another.

I'm talking about the oysters that once protected New Yorkers from storm surges, a bivalve population that numbered in the trillions and that played a critical role in stabilizing the shoreline from Washington to Boston.

Mr. Obama has backed President George W. Bush's hallmark anti-AIDS program called PEPFAR and his administration has played critical roles in stabilizing Somalia, combating piracy and helping many African countries counter terrorist groups.